A cosmic event in 2015 fused earth with the faerie realm. Scientists refer to the event as the Anomaly. A byproduct of the Anomaly was the advent of hybrid beings - people who became mixed with whatever animal or object was nearest them the moment the Anomaly occurred. Humans, or Pedigrees, soon relegated fairy refugees and hybrids into ghetto zones in large cities.
Seventy years later, Wolfgang Rex, a second-generation hybrd - part human, part Rhodesian Ridgeback - is a retired police detective who runs a private investigation business in Chicago's Southside. It's a one-hybrid show: though Rex couldn't survive without his assisstant, the faerie Sally Sandweb.
One evening, two vampires visit Rex and offer him a substantial reward for the recovery of a stolen scroll. Later that evening, Charlotte Sweeney-Jarhadill, a Pedigree woman from Lousiana, visits Rex and hires him to exorcise the headless ghost of a confederate soldier from her home.
To complicate matters, the private detective ends up falling for Charlotte. Meanwhile the vampires demand results in the search for the missing scroll. When Rex's assistant Sally goes missing, he must stay alive long enough to find her. Charlotte and the vampires, however, have other plans for Rex.